How to Invest in Tomorrow’s Tech Trends Today

Which companies, public and private, are best-positioned for the next 100 years—or at least the next few years? We put the question to Jerry Yang, founding partner of AME Cloud Ventures and co-founder of Yahoo!, and a member of Barron’s Centennial Roundtable. Yang, a longtime venture capitalist based in Silicon Valley, has seen his share of start-ups and innovations. He highlights some of today’s most promising companies and trends in the edited interview below.

Barron’s: Which companies excite you these days, and why?

Jerry Yang: I’ll start with Zoom Video Communications [ticker: ZM]. Never in a thousand years would we have thought that ‘Zoom’ would become a verb in this context. This company took the opportunity to become massively skilled in the past 15 months. In hindsight, we might say it was easy for them to have done that, but they had to overcome a lot of privacy and scale issues. They really matured in a hurry. The future for video is huge. How do we enhance it? How do we make video more intelligent and productive?

Will the future belong to Zoom or a host of competitors?

From the big competitors to start-ups, everyone is emulating or attempting to catch up to Zoom’s capabilities. Zoom has announced a platform marketplace for applications. It is adding more intelligence to its platform, and more productivity tools. In my view, by launching an app store of sorts, Zoom can create an ecosystem that is a defensible barrier to competition.

Zipline, an on-demand delivery service, is another company to watch. It operates fixed-wing drones that carry a few kilograms of payload. They can fly 160 kilometres round trip. When they reach their destination, they drop an insulated package with a parachute. Zipline was founded in Silicon Valley, but its first scaled deployment is medical supply in Rwanda, Africa. Zipline delivers blood supplies and critical medicines. It continues to scale. It is an incredibly exciting company.

Do you expect Zipline to go public in the next few years?

That’s a good question. Companies are raising as much money now in private funding rounds as they would have in an initial public offering. IPOs help with branding and maybe create a new investor base, but if a company just needs capital, there is plenty in the private market. From 2012 to 2015 or ’16, there were few companies coming public. The IPO market goes in cycles. With today’s abundance of low-cost capital, private companies can take risks and have the money to grow.

What other industries or companies look promising to you?

In the area of artificial intelligence and drug discovery, we invested in Recursion Pharmaceuticals [RXRX], which went public in April. Recursion is based in Salt Lake City, which has become a hotbed for biotech start-ups. The company uses massive data computational tools, lab robotics, and a petabyte-level database to speed up the drug-discovery process. Zymergen [ZY] also operates in an area I’m pretty excited about—biofacturing. This is a materials manufacturing company, using AI, automation, and biology for scale manufacturing.

How does biology fit into the equation?

Instead of using chemicals, for instance, they’re using yeast fermentation to make new materials and products—from new electronic displays to naturally derived bug repellents. Ginkgo Bioworks is another biofacturing company I’m excited about. More broadly, the birth of genetic sequencing launched a whole industry that’s exciting, including gene editing. Synthetic biology is at an early stage, but we’re already starting to see companies come to fruition, such as Twist Bioscience [TWST], which manufactures and sells synthetic DNA-based products. The world will need more of these technologies in coming years. Ten years ago, we hadn’t “printed” a single gene. Now we’re printing tens of millions, and that will go to billions in the next few years.

What other technologies should we be watching?

I’ll emphasize a couple of trends. We’re moving into a world where cameras will be smarter. Whether cameras are manned by Zoom apps or cars or your watch, they will be equipped with more sensors, and the sensors will get smarter. That means more data will be fed into the cloud. We’re also seeing huge investments in natural-language processing. A lot of theoretical work was done in this area, and now we’re starting to see practical applications. All of this means the cloud is getting smarter. We’re going to need a lot more bandwidth. If we build bandwidth, the applications will come. Sensors and devices will be communicating with each other, without human intervention. That’s another massive source of new data that will come online.

The idea of using biomaterials in sensors is still in the research lab, but it’s something to watch. Sensors made of carbon, instead of silicon, could be much more responsive to an individual’s biology.

We haven’t talked about longevity. Science tells us the average life span for today’s teenagers could be well beyond 100.

An original watercolour illustration for the cover of Harry Potter and the Philosopher’s Stone, 1997 — the first book in J.K. Rowling’s hit series—could sell for US$600,000 at a Sotheby’s auction this summer.

The illustration is headlining a June 26 sale in New York that will also feature big-ticket items from the collection of the late Dr. Rodney P. Swantko, a surgeon and collector from Indiana, including manuscripts by poet Edgar Allan Poe and Arthur Conan Doyle, author of the Sherlock Holmes books

The Harry Potter illustration, which introduced the young wizard character to the world, is expected to sell for between US$400,000 to US$600,000, which would make it the highest-priced item ever sold related to the Harry Potter world. This is the second time the illustration has been sold, however—it was on the auction block at Sotheby’s in London in 2001, where it achieved £85,750 (US$107,316).

The artist of the illustration, Thomas Taylor, was 23 years old at the time and a graduate student working at a children’s bookshop. According to Sotheby’s, Taylor took a “professional commission from an unknown author to visualise a unique wizarding world,” Sotheby’s said in a news release. He depicted Harry Potter boarding the train to Hogwarts on platform9 ¾ platform, and the illustration became the “universal image” of the Harry Potter series, Sotheby’s said.

“It is exciting to see the painting that marks the very start of my career, decades later and as bright as ever! It takes me back to the experience of reading Harry Potter for the first time—one of the first people in the world to do so—and the process of creating what is now an iconic image,” Taylor said in the release.

Meanwhile, to commemorate the 175th anniversary of Edgar Allan Poe’s For Annie , 1849, Sotheby’s recently reunited the autographed manuscript of the poem with the author’s home, Poe Cottage, in the Bronx.

The cottage is where the author lived with his wife, Virginia, and mother-in-law, Maria Clemm, from 1846 until he died in 1849. The manuscript, also from the Swantko collection, will remain at the home until it is offered at auction at Sotheby’s on June 26 with an estimate between US$400,000 and US$600,000.

The autographed manuscript will remain at Poe Cottage until it is offered at auction at Sotheby’s on June 26.
Matthew Borowick for Sotheby’s

Poe Cottage, preserved and overseen by the Bronx County Historical Society, is home to many of the author’s famous works, including Eureka , 1948, and Annabel Lee , 1927.

“To reunite the For Annie manuscript with the Poe Cottage nearly two centuries after it was first composed brought to life literary history for a truly special and unique occasion,” Richard Austin , Sotheby’s Global Head of Books & Manuscripts, said in a news release.

For Annie was one of Poe’s most important compositions, and was addressed to Nancy “Annie” L. Richmond, one of the several women Poe pursued after his wife Viriginia’s death from tuberculosis in 1847.

In a letter to Richmond herself, Poe proclaimed For Annie was his best work: “I think the lines For Annie much the best I have ever written.”

The poem was composed in 1849, only months before Poe’s death, Sotheby’s said in the piece, Poe highlights the romantic comfort he feels from a woman named Annie while simultaneously grappling with the darkness of death, with lines like “And the fever called ‘living’ is conquered at last.”

Poe Cottage, preserved and overseen by the Bronx County Historical Society, is home to many of the author’s famous works, including Eureka, 1948, and Annabel Lee,, 1927.
Matthew Borowick for Sotheby’s

In the margins of the manuscript are the original handwritten instructions by Nathaniel P. Willis, co-editor of the New York Home Journal, where Poe published other poems such as The Raven and submitted For Annie on April 20, 1849.

Willis added Poe’s name in the top right and instructions about printing and presenting the poem on the side. The poem was also published in the Boston Weekly that same month.

Another piece of literary history included in the Swantko sale could surpass US$1 million. Conan Doyle’s autographed manuscript of the Sherlock Holmes tale The Sign of Four , 1889, is estimated to achieve between US$800,000 and US$1.2 million.

How to Invest in Tomorrow’s Tech Trends Today

We put the question to Jerry Yang co-founder of Yahoo!