How Old Are You Really? Meet Your ‘Biological Age’
Biological age won’t help you live forever, but a ‘credit score for your body’ might prolong your lifespan, some scientists say.
4 min
Biological age—a measure of health that can be more or less than your chronological age—might help determine your quality of life as you get older, scientists say.
The idea behind biological age is that your cells and organs have ages that vary from your regular age. Many aging-research scientists believe that knowing your biological age could help you postpone or avoid Alzheimer’s, cancer, cardiovascular disease or other age-related illnesses. Some also believe biological age can better predict an individual’s lifespan.
Other scientists agree that biological age is important but disagree that it can predict your life. They say there is no standard way to measure biological age and many of the tools in development aren’t yet proven. At the centre of the debate are hopes that people can prolong their lives by changing their behaviours; a crop of companies are betting on it.
David Sinclair, professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, is among the researchers and entrepreneurs promoting the notion of a biological age. He describes it as “like a credit score for your body.”
Dr. Sinclair is 52 chronologically but says he is biologically more like 42. Dr. Sinclair is a co-founder of a new company that is developing a biological-age test.
Some scientists calculate the metric by analyzing biomarkers in blood or saliva; other scientists and engineers do it by comparing individuals with broader aging patterns.
The activities that influence biological age—such as sleep, exercise and diet—are essentially the good habits we already know about. But since everybody’s genes are different, tracking your biological age could help determine which habits are most helpful and how to customize them. For one person, 10,000 steps a day could be optimal, while it is 6,000 for someone else.
People also can attempt to lower their biological age through meditation, yoga or other ways of effectively managing stress. Some, including Dr. Sinclair, use supplements to try to make themselves younger.
Scientists studying aging hope that eventually, individuals will be able to accurately measure their biological age and uncover the steps that influence it to forestall chronic disease and possibly live longer.
Even so, some scientists are sceptical of the process. Some think that even if you do know your biological age, it is a stretch to believe that you could use the concept to help you live longer.
Alex Zhavoronkov, chief executive of Insilico Medicine, which uses artificial intelligence to develop drugs targeting age-related diseases, says biological age is a useful concept for drug development. But he says he doubts that people will be able to use behaviours to live longer, based on studies of lifespan in different countries around the world.
“Extreme optimization of sleep, exercise and diet is unlikely to result in dramatic lifespan increases,” he says.
Growing interest in biological age is fueled by advances in the field of epigenetics, the study of how gene expression is affected by behaviours and the environment.
Dr. Sinclair at Harvard is developing a biological-age test based on chemical changes on DNA found in cells from the side of the cheek taken in a swab you do at home. He plans to launch it with a new company called Tally Health.
Dr. Sinclair has been criticized by other scientists for hyping the results of some of his findings, like the antiaging effects found in the compound resveratrol, claims he rebuts. He says that he doesn’t overstate his research findings and that the resveratrol research was published in leading scientific journals. He has co-founded more than a dozen biotech companies and is invested in most of them, including some that are developing therapeutics that target the biology of aging.
Segterra Inc.’s InsideTracker, a personalized-nutrition company founded by scientists from Harvard, Tufts University and the Massachusetts Institute of Technology, calculates biological age by having users take blood tests and analyzing the samples for markers of conditions like inflammation, heart health and liver or kidney disorder. Those who test as older than their years get recommendations to adjust diet, exercise and supplements.
Many other health startups are offering testing that purports to calculate biological age, sometimes with little scientific backing, and designing supplements aimed at boosting youthfulness.
Stephen Roberts, a winery owner in France, tested himself earlier this year with an at-home blood test by U.K.-based biotech company GlycanAge Ltd. The test was part of an effort by Mr. Roberts to improve his health at age 51.
“I drink. I sometimes smoke and party and eat what I want,” he says, so he expected his biological age to be a lot older than his calendar age.
He says he was shocked when test results reported hisbiological age was 24.
“My first reaction was: ‘This is wrong.’” He says he hasn’t made any changes as a result of the test but plans to test again later this year.
Gordan Lauc, professor of biochemistry and molecular biology at the University of Zagreb, in Croatia, and chief scientific officer of GlycanAge, says the results make sense given Mr. Roberts’s genetics—longevity runs in his family—and lifestyle, which is likely lower-stress than most.
Michael Roizen, an anesthesiologist and chief wellness officer emeritus at the Cleveland Clinic, created one of the first biological age calculators 25 years ago based on a questionnaire. He sold it to digital health company Sharecare Inc., where he receives stock options as a member of its scientific advisory board.
Dr. Roizen now has a book and website due out in the spring, part of a new company he says will be aimed at helping people understand how to live longer.
Exercise, for instance, does more than strengthen your heart, he says. Working out switches on a gene that starts a chain reaction that increases secretion of a protein that improves memory, studies show. Your methods of managing stress can switch on or off the functioning of more than 250 genes, Dr. Roizen says.
“Your choices have a much more profound effect than just changing whether your heart is beating fast or slow,” says Dr. Roizen.
Reprinted by permission of The Wall Street Journal, Copyright 2021 Dow Jones & Company. Inc. All Rights Reserved Worldwide. Original date of publication: May 24, 2022.
Chris Dixon, a partner who led the charge, says he has a ‘very long-term horizon’
Americans now think they need at least $1.25 million for retirement, a 20% increase from a year ago, according to a survey by Northwestern Mutual
Competitive pressure and creativity have made Chinese-designed and -built electric cars formidable competitors
4 min
China rocked the auto world twice this year. First, its electric vehicles stunned Western rivals at the Shanghai auto show with their quality, features and price. Then came reports that in the first quarter of 2023 it dethroned Japan as the world’s largest auto exporter.
How is China in contention to lead the world’s most lucrative and prestigious consumer goods market, one long dominated by American, European, Japanese and South Korean nameplates? The answer is a unique combination of industrial policy, protectionism and homegrown competitive dynamism. Western policy makers and business leaders are better prepared for the first two than the third.
Start with industrial policy—the use of government resources to help favoured sectors. China has practiced industrial policy for decades. While it’s finding increased favour even in the U.S., the concept remains controversial. Governments have a poor record of identifying winning technologies and often end up subsidising inferior and wasteful capacity, including in China.
But in the case of EVs, Chinese industrial policy had a couple of things going for it. First, governments around the world saw climate change as an enduring threat that would require decade-long interventions to transition away from fossil fuels. China bet correctly that in transportation, the transition would favour electric vehicles.
In 2009, China started handing out generous subsidies to buyers of EVs. Public procurement of taxis and buses was targeted to electric vehicles, rechargers were subsidised, and provincial governments stumped up capital for lithium mining and refining for EV batteries. In 2020 NIO, at the time an aspiring challenger to Tesla, avoided bankruptcy thanks to a government-led bailout.
While industrial policy guaranteed a demand for EVs, protectionism ensured those EVs would be made in China, by Chinese companies. To qualify for subsidies, cars had to be domestically made, although foreign brands did qualify. They also had to have batteries made by Chinese companies, giving Chinese national champions like Contemporary Amperex Technology and BYD an advantage over then-market leaders from Japan and South Korea.
To sell in China, foreign automakers had to abide by conditions intended to upgrade the local industry’s skills. State-owned Guangzhou Automobile Group developed the manufacturing know-how necessary to become a player in EVs thanks to joint ventures with Toyota and Honda, said Gregor Sebastian, an analyst at Germany’s Mercator Institute for China Studies.
Despite all that government support, sales of EVs remained weak until 2019, when China let Tesla open a wholly owned factory in Shanghai. “It took this catalyst…to boost interest and increase the level of competitiveness of the local Chinese makers,” said Tu Le, managing director of Sino Auto Insights, a research service specialising in the Chinese auto industry.
Back in 2011 Pony Ma, the founder of Tencent, explained what set Chinese capitalism apart from its American counterpart. “In America, when you bring an idea to market you usually have several months before competition pops up, allowing you to capture significant market share,” he said, according to Fast Company, a technology magazine. “In China, you can have hundreds of competitors within the first hours of going live. Ideas are not important in China—execution is.”
Thanks to that competition and focus on execution, the EV industry went from a niche industrial-policy project to a sprawling ecosystem of predominantly private companies. Much of this happened below the Western radar while China was cut off from the world because of Covid-19 restrictions.
When Western auto executives flew in for April’s Shanghai auto show, “they saw a sea of green plates, a sea of Chinese brands,” said Le, referring to the green license plates assigned to clean-energy vehicles in China. “They hear the sounds of the door closing, sit inside and look at the quality of the materials, the fabric or the plastic on the console, that’s the other holy s— moment—they’ve caught up to us.”
Manufacturers of gasoline cars are product-oriented, whereas EV manufacturers, like tech companies, are user-oriented, Le said. Chinese EVs feature at least two, often three, display screens, one suitable for watching movies from the back seat, multiple lidars (laser-based sensors) for driver assistance, and even a microphone for karaoke (quickly copied by Tesla). Meanwhile, Chinese suppliers such as CATL have gone from laggard to leader.
Chinese dominance of EVs isn’t preordained. The low barriers to entry exploited by Chinese brands also open the door to future non-Chinese competitors. Nor does China’s success in EVs necessarily translate to other sectors where industrial policy matters less and creativity, privacy and deeply woven technological capability—such as software, cloud computing and semiconductors—matter more.
Still, the threat to Western auto market share posed by Chinese EVs is one for which Western policy makers have no obvious answer. “You can shut off your own market and to a certain extent that will shield production for your domestic needs,” said Sebastian. “The question really is, what are you going to do for the global south, countries that are still very happily trading with China?”
Western companies themselves are likely to respond by deepening their presence in China—not to sell cars, but for proximity to the most sophisticated customers and suppliers. Jörg Wuttke, the past president of the European Union Chamber of Commerce in China, calls China a “fitness centre.” Even as conditions there become steadily more difficult, Western multinationals “have to be there. It keeps you fit.”
Chris Dixon, a partner who led the charge, says he has a ‘very long-term horizon’
Americans now think they need at least $1.25 million for retirement, a 20% increase from a year ago, according to a survey by Northwestern Mutual
