The Longevity Vacation: Poolside Lounging With an IV Drip
The latest trend in wellness travel is somewhere between a spa trip and a doctor’s appointment
4 min
For some vacationers, the ideal getaway involves $1,200 ozone therapy or an $1,800 early-detection cancer test.
Call it the longevity vacation. People who are fixated on optimising their personal health are pursuing travel activities that they hope will help them stay healthier for longer. It is part of a broader interest in longevity that often extends beyond traditional medicine . These costly trips and treatments are rising in popularity as money pours into the global wellness travel market.
At high-end resorts, guests can now find biological age testing, poolside vitamin IV drips, and stem-cell therapy. Prices can range from hundreds of dollars for shots and drips to tens of thousands for more invasive procedures, which go well beyond standard wellness offerings like yoga, massages or facials.
Some longevity-inspired trips focus on treatments, while others focus more on social and lifestyle changes. This includes programs that promise to teach travellers the secrets of centenarians .
Mark Blaskovich, 66 years old, spent $4,500 on a five-night trip last year centred on lessons from the world’s “Blue Zones,” places including Sardinia, Italy, and Okinawa, Japan, where a high number of people live for at least 100 years. Blaskovich says he wanted to get on a healthier path as he started to feel the effects of ageing.
He chose a retreat at Modern Elder Academy in Mexico, where he attended workshops detailing the power of supportive relationships, embracing a plant-based diet and incorporating natural movement into his daily life.
“I’ve been interested in longevity and trying to figure out how to live longer and live healthier,” says Blaskovich.
Vitamins and ozone
When Christy Menzies noticed nurses behind a curtained-off area at the Four Seasons Resort Maui in Hawaii on a family vacation in 2022, she assumed it might be Covid-19 testing. They were actually injecting guests with vitamin B12.
Menzies, 40, who runs a travel agency, escaped to the longevity clinic between trips to the beach, pool and kids’ club, where she reclined in a leather chair, and received a 30-minute vitamin IV infusion.
“You’re making investments in your wellness, your health, your body,” says Menzies, who adds that she felt more energised afterward.
The resort has been expanding its offerings since opening a longevity centre in 2021. A multi-day treatment package including ozone therapy, stem-cell therapy and a “fountain of youth” infusion, costs $44,000. Roughly half a dozen guests have shelled out for that package since it made its debut last year, according to Pat Makozak, the resort’s senior spa director. Guests can also opt for an early-detection cancer blood test for $1,800.
The ozone therapy, which involves withdrawing blood, dissolving ozone gas into it, and reintroducing it into the body through an IV, is particularly popular, says Makozak. The procedure is typically administered by a registered nurse, takes upward of an hour and costs $1,200.
Longevity vacationers are helping to fuel the global wellness tourism market, which is expected to surpass $1 trillion in 2024, up from $439 billion in 2012, according to the nonprofit Global Wellness Institute. About 13% of U.S. travellers took part in spa or wellness activities while traveling in the past 12 months, according to a 2023 survey from market-research group Phocuswright.
Canyon Ranch, which has multiple wellness resorts across the country, earlier this year introduced a five-night “Longevity Life” program, starting at $6,750, that includes health-span coaching, bone-density scans and longevity-focused sessions on spirituality and nutrition.
The idea is that people will return for an evaluation regularly to monitor progress, says Mark Kovacs, the vice president of health and performance.
What doctors say
Doctors preach caution, noting many of these treatments are unlikely to have been approved by the Food and Drug Administration, producing a placebo effect at best and carrying the potential for harm at worst. Procedures that involve puncturing the skin, such as ozone therapy or an IV drip, risk possible infection, contamination and drug interactions.
“Right now there isn’t a single proven treatment that would prolong the life of someone who’s already healthy,” says Dr. Mark Loafman, a family-medicine doctor in Chicago. “If it sounds too good to be true, it probably is.”
Some studies on certain noninvasive wellness treatments, like saunas or cold plunges , do suggest they may help people feel less stressed, or provide some temporary pain relief or sleep improvement.
Linda True, a policy analyst in San Francisco, spent a day at RAKxa, a wellness retreat on a visit to family in Thailand in February. True, 46, declined the more medical-sounding offerings, like an IV drip, and opted for a traditional style of Thai massage that involved fire and is touted as a “detoxification therapy.”
“People want to spend money on things that they feel might be doing good,” says Dr. Tamsin Lewis, medical adviser at RoseBar Longevity at Six Senses Ibiza, a longevity club that opened last year, whose menu includes offerings such as cryotherapy, infrared sauna and a “Longevity Boost” IV.
RoseBar says there is good evidence that reducing stress contributes to longevity, and Lewis says she doesn’t offer false promises about treatments’ efficacy . Kovacs says Canyon Ranch uses the latest science and personal data to help make evidence-based recommendations.
Jaclyn Sienna India owns a membership-based, ultra luxury travel company that serves people whose net worth exceeds $100 million, many of whom give priority to longevity, she says. She has planned trips for clients to Blue Zones, where there are a large number of centenarians. On one in February, her company arranged a $250,000 weeklong stay for a family of three to Okinawa that included daily meditation, therapeutic massages and cooking classes, she says.
India says keeping up with a longevity-focused lifestyle requires more than one treatment and is cost-prohibitive for most people.
Doctors say travellers may be more likely to glean health benefits from focusing on a common vacation goal : just relaxing.
Dr. Karen Studer, a physician and assistant professor of preventive medicine at Loma Linda University Health says lowering your stress levels is linked to myriad short- and long-term health benefits.
“It may be what you’re getting from these expensive treatments is just a natural effect of going on vacation, decreasing stress, eating better and exercising more.”
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At least for people who carry the APOE4 genetic variant, a juicy steak could keep the brain healthy.
3 min
Must even steak be politicised? The American Heart Association recently recommended eating more “plant-based” protein in a move to counter the Health and Human Services Department’s new guidelines calling for more red meat.
Few would argue that eating a Big Mac a day is good for you.
On the other hand, growing evidence, including a study last month in the Journal of the American Medical Association, suggests that eating more meat—particularly unprocessed red meat—can reduce the risk of Alzheimer’s in the quarter or so of people with a particular genetic predisposition.
The APOE4 gene variant is one of the biggest risk factors for Alzheimer’s.
You inherit one copy of the APOE gene from each parent. The most common variant is APOE3; the least is APOE2.
The latter carries a lower risk of Alzheimer’s, while the former is neutral. A quarter of people carry one copy of the APOE4 variant, and about 2% carry two.
APOE4 is more common among people with Northern European and African ancestry. In Europe the variant increases with latitude, and is present in as many as 27% of people in northern countries versus 4% in southern ones. God smiled on the Italians and Greeks.
For unknown reasons, the APOE4 variant increases the risk of Alzheimer’s far more for women than men.
Women’s risk multiplies roughly fourfold if they have one copy and tenfold if they have two. Men with a single copy show little if any higher risk, while those with two face four times the risk.
What makes APOE4 so pernicious? Scientists don’t know exactly, but the variant is also associated with higher cholesterol levels—even among thin people who eat healthily.
Scientists have found that cholesterol builds up in brain cells of APOE4 carriers, which can disrupt communications between neurons and generate amyloid plaque, an Alzheimer’s hallmark.
The Heart Association’s recommendation to eat less red meat may be sound advice for people with high cholesterol caused by indulgent diets.
But a diet high in red meat may be better for the brains of APOE4 carriers.
In the JAMA study, researchers at Sweden’s Karolinska Institute examined how diet, particularly meat consumption, affects dementia risk among seniors with the different APOE variants.
Higher consumption of meat, especially unprocessed red meat, was associated with significantly lower dementia risk for APOE4 carriers.
APOE4 carriers who consumed the most meat—the equivalent of 4.5 ounces a day—were no more likely to develop dementia than noncarriers. (
The study controlled for other variables that are known to affect Alzheimer’s risk including sex, age, physical activity, smoking, alcohol consumption and education.)
APOE4 carriers who ate the most unprocessed meat were at significantly lower risk of dying over the study’s 15-year period and had lower cholesterol than carriers who ate less. Go figure. Noncarriers, however, didn’tenjoy similar benefits from eating more red meat.
The study’s findings are consistent with two large U.K. studies.
One found that each additional 50 grams of red meat (equivalent to half a hamburger patty) that an APOE4 carrier consumed each day was associated with a 36% reduced risk of dementia.
The other found that older women who carried the APOE4 variant and consumed at least one serving a day of unprocessed red meat had a cognitive advantage over carriers who ate less than half a serving, and that this advantage was of roughly equal magnitude to the cognitive disadvantage observed among APOE4 carriers in general.
In all three studies, eating more red meat appeared to negate the increased genetic risk of APOE4.
Perhaps one reason men with the variant are at lower Alzheimer’s risk than women is that men eat more red meat.
These findings might cause chagrin to women who rag their husbands about ordering the rib-eye instead of the heart-healthy salmon.
But remember, the cognitive benefits of eating more red meat appear isolated to APOE4 carriers.
Nutrition is complicated, and categorical recommendations—other than perhaps to avoid nutritionally devoid foods—would best be avoided by governments and health bodies.
Readers can order an at-home test from any number of companies to screen for the APOE4 variant.
The Swedish researchers hypothesize that APOE4 carriers may be evolutionarily adapted to carnivorous diets, since the variant is believed to have emerged between one million and six million years ago during a “hypercarnivorous” period in human history.
The other two APOE variants originated more recently, during eras when humans ate more plants.
APOE4 carriers may absorb more nutrients from meat than plants, the researchers surmise. Vitamin B12—low levels have been associated with cognitive decline—isn’t naturally present in plant-based foods but is abundant in red meat.
Foods high in phytates (such as grains and beans) can interfere with absorption of zinc and iron (also high in red meat), which naturally declines with age. So maybe don’t chuck your steak yet.
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