The Secret to Living to 100? It’s Not Good Habits
Good genes matter more the older you get
Good genes matter more the older you get
If you want to live to your 100th birthday, healthy habits can only get you so far.
Research is making clearer the role that genes play in living to very old age. Habits like getting enough sleep, exercising and eating a healthy diet can help you stave off disease and live longer, yet when it comes to living beyond 90, genetics start to play a trump card, say researchers who study aging.
“Some people have this idea: ‘If I do everything right, diet and exercise, I can live to be 150.’ And that’s really not correct,” says Robert Young, who directs a team of researchers at the nonprofit scientific organisation Gerontology Research Group.
About 25% of your ability to live to 90 is determined by genetics, says Dr. Thomas Perls, a professor of medicine at Boston University who leads the New England Centenarian Study, which has followed centenarians and their family members since 1995. By age 100, it’s roughly 50% genetic, he estimates, and by around 106, it’s 75%.
Knowing what enables some people to live very long lives has consequences for the rest of us. Ongoing research into very old agemay help provide insight that could eventually be used to develop drugs or identify lifestyle changes to help people live healthier for longer, says Dr. James Kirkland, president of the American Federation for Aging Research.
Centenarians make up a growing share of the U.S. population. There are about 109,000 centenarians living in the country in 2023, according to Census Bureau projections, up from about 65,000 10 years ago, thanks in part to decades of advances in medicine and public health.
Despite a decline in life expectancy, which dropped to 76.4 in 2021, Perls estimates that roughly 20% of the population has the genetic makeup that could get them to 100 if they also make consistent healthy choices.
Not only do centenarians live longer, but data suggest they manage to avoid or delay age-related diseases like cancer, dementia and cardiovascular disease longer than the general population. Among the New England Centenarian Study participants, 15% are “escapers,” or people with no demonstrable disease at the age of 100; some 43% are “delayers,” those who didn’t develop age-related disease until age 80 or after.
Chuck Ullman, who is 97 and lives in a retirement community in Thousand Oaks, Calif., says he is free of health problems—aside from a sore right shoulder from a recent electric biking accident—and has no desire to live to a particular age. He hopes to live as long as he feels good and can do the things he loves, such as woodworking, attending political discussion groups and getting dinner with some of his many friends.
“There are 350 residents here, and I have 350 friends,” Ullman says of his community. He also spends time with Betty, his wife of 77 years. “My objective is to enjoy each and every day that comes along.”
Researchers have identified some genes and combinations of them that are associated with longevity, such as the presence of a variant of what’s known as the apolipoprotein E gene called e2, a trait thought to help protect against Alzheimer’s. They emphasize each trait is a small piece in a large, complicated puzzle, which can factor in socioeconomic status, race and ethnicity, and climate.
Living past 100 requires a combination of many genetic variants, each with a relatively modest effect, says Perls of the New England Centenarian Study.
Gene variants that offer protective qualities, such as repairing DNA damage, are especially beneficial, he says.
People who are curious about how long they might live should start by looking at their family histories. Your relatives’ lifespans are one of the strongest predictors of longevity, says Perls. Ullman, the 97-year-old, says his mother lived to 90.
If multiple members of your family have lived into very advanced age, “you’ve potentially won a much greater chance of having purchased the right lottery ticket,” says Perls.
Neurologist Dr. Claudia Kawas has been tracking the habits of the “oldest old,” those older than 90, in Southern California since 2003, as part of a study at the University of California, Irvine. She and a team of researchers have found links between longevity and even short amounts of exercise, social activities such as going to church, and modest caffeine and alcohol intake.
“Super-agers,” or people over the age of 80 whose cognitive abilities are on par with those 20 to 30 years younger, reported having more warm, trusting, high-quality relationships with other people than cognitively normal participants, investigators at Northwestern University found.
“Keeping in good relationships could be one key to health span,” says Amanda Cook Maher, a neuropsychologist at the University of Michigan and lead author of the study.
Your outlook also matters. Harvard researchers identified a link between optimism and longer lifespans in women across racial and ethnic groups. Among the study participants, the 25% who were the most optimistic had a greater likelihood of living beyond 90 years than the least-optimistic 25%, according to the 2022 study published in the Journal of the American Geriatrics Society.
Jeanne Case, 100, says she has taken a glass-half-full approach to life.
She plans to outlive her colon and skin cancers and keep enjoying swing music and Mexican food as long as she feels physically and mentally well.
A day in her life can include walking a mile, conversing with her writing group or noshing on fish tacos with friends. The Irvine, Calif., resident has always exercised but also enjoys indulgences like cheesecake and lemon bars.
“I try not to let stress bother me,” she says.
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Artificial intelligence is making it easier than ever to build a business without building a team. As AI takes over coding, customer support, marketing, administration, and other day-to-day tasks, a growing number of solo founders are scaling startups to millions in revenue with few—or even no—employees. While the trend is lowering barriers to entrepreneurship, it is also reshaping hiring, raising questions about the future of work and how businesses will grow in the AI era.
Ben Broca launched a company last December that offers AI tools to entrepreneurs. He’s already added 10,000 paying customers and is on track to bring in $10 million in revenue this year.
One thing he hasn’t added: any other employees.
The 40-year-old is part of a class of entrepreneurs who are launching, and then often running, new companies on their own. Artificial intelligence tools answer Broca’s emails, help write and debug code, field requests from customers, sign up new subscribers and grant refunds when issues arise.
Broca relishes his ability to make whatever decisions he wants on his own, often from his sun-drenched Sausalito, Calif., living room. “I think compromises make lukewarm results,” he said.
Once upon a time, running a business of a certain size required a team. AI is turning that assumption upside down, and more aspiring entrepreneurs are going it alone.
An analysis by the payments company Stripe shows there are thousands of solo operators on the company’s platform that are generating over $1 million in revenue, with their ranks doubling between 2023 and 2025. The number of solo operators crossing the $10 million threshold nearly tripled in that same span.
In the past, people without business contacts or particular savvy might not have known how to get their ideas off the ground, said Ernie Tedeschi, Stripe’s chief economist. “Now, AI can be a built-in business partner,” he said.
AI’s ability to handle various administrative tasks makes it potentially useful for launching solo businesses in many fields. But the technology’s ability to also handle key tasks in tech, like coding, make that field a particular hot spot.
Analyzing Census Bureau data, Bank of America Institute economist Taylor Bowley found that among all industries, new business applications in the information sector have seen the biggest percentage increase—nearly 45%—over the past year. At the same time, the rate of information-sector applicants saying they plan to hire workers has experienced the sharpest decline of any measured industry.
This Census dataset doesn’t track solo-operated businesses. But the numbers broadly show—in tech and beyond—that applications are flat among businesses likely to hire workers, but generally rising elsewhere. Economists say that’s a strong sign that solo operators are on the upswing.
“The bar for getting started has never been lower,” said Julian Weisser, who runs a San Francisco-based accelerator for solo founders working in tech. The accelerator—which offers founders seed money and mentorship in exchange for an equity stake—attracted 4,500 applicants for 10 slots made available in its most recent cycle, nearly five times the number it drew when it launched last May.
Going it alone with AI can still be surprisingly expensive. Broca said he was losing money on many customers’ accounts while paying to access Anthropic’s Claude to run his clients’ requests—that AI company, as well as others, charges based on usage. He has since switched to free open-source AI models from China.
Broca said he has raised $30 million from investors and, at the same time, has saved millions in salary since he hasn’t needed a team of software engineers.
Another risk: If it’s easy for one entrepreneur to launch an AI-assisted business, copying them can be easy, too. This creates anxiety for founders like Troy Johnston, who runs an AI-assisted business alone in Orlando, Fla.
“Everybody has the sword and we all have the ability to unsheathe Excalibur now,” said Johnston, 40, who used AI to code an app that helps people get the most out of credit card benefits. The company makes around $3,000 a month in profit, with no employees, and is continuing to grow.
What one-person businesses will mean for the labor market remains to be seen. Polling has shown Americans are worried that AI will replace jobs, and top economists are wrestling with that possibility, too. But AI is also creating lots of new jobs, and the go-it-alone entrepreneurs show how the technology can both open doors and limit employment opportunities.
“If everyone’s hiring less, but you get four times more firms, what does that do to head count?” said Rembrand Koning, an associate professor at Harvard Business School who studies entrepreneurship. He co-authored a recent study that found that among 50,000 startups the researchers examined, those focused on AI tended to operate with 25% fewer employees.
Koning also believes a soft hiring environment that’s left some people mired in long job searches has encouraged more to try their hand at launching businesses.
Some founders cite different motives. “It’s a perfect storm of post-pandemic burnout and a re-evaluation of one’s priorities, and also booming AI and a sense of what’s possible,” said Samir Ahmad, 39, who lives in Breinigsville, Pa.
Two years ago, Ahmad decided to leave the corporate job he had worked at Verizon for almost two decades to start a solo coaching and consulting business. He had been seeing social-media posts touting the ease and virtues of AI, which he used to chart a business plan and help with marketing. “It was like my chief of staff, a second in command,” he said.
The business ultimately petered out within months, though, and Ahmad is now back to a full-time corporate role with a utility company.
For Claire Vo, 41, AI helped her turn a passing impulse into a business. She was working full-time as a tech executive when she tapped AI in late 2023 to help code an app that would help her manage documentation and design for new products, with customers ranging from financial services to healthcare firms.
“I was copying and pasting from ChatGPT,” said Vo, who lives in San Francisco.
She put the app online for $1 a month, and within weeks people downloaded it thousands of times. Nearly three years later, Vo’s company—which she ran solo for nine months before hiring an engineer—now has 100,000 users and is on track to make seven figures in profit this year. AI handles the company’s marketing, sales and customer support.
While AI is a shortcut, Vo said her network and credibility in the industry were key. “I think people over-index on how easy AI is and under-index on how much I did to get to this point,” she said.
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