During the Covid pandemic in 2021, Silicon Valley venture capitalist John O’Farrell organised a call with several tech CEOs to urge them to back Unicef’s efforts to distribute vaccines globally as he and his wife, Gloria Principe, were doing.
Stewart Butterfield , co-founder and—at the time—the CEO of Slack, and his wife, Jen Rubio , co-founder and CEO of Away, “gave US$25 million on the spot,” and challenged other tech CEOs to give, too, says Kristen Jones, Unicef’s fundraising manager, global philanthropy.
O’Farrell is on the national board of the organisation and a member of the Unicef International Council, a network of 150 wealthy individuals from 22 countries.
“We were trying to mobilise resources really quickly,” Jones says. In this instance, an International Council member showed how the “influence and trust” of individuals and their network can be extended to Unicef and its mission.

Courtesy of Unicef
Unicef, officially the United Nations Children’s Fund, is a U.N. agency focused on humanitarian and developmental aid to children. It relies on funding from governments and intergovernmental agencies. But it also depends on the private sector, from US$1 gifts provided by individuals across the world to giving by corporations, foundations, and wealthy donors.
Total giving to Unicef from the private sector totalled US$2.07 billion last year, representing 23% of total revenue, according to its annual report. Of that total, US$829 million was unrestricted—money that is particularly valuable because it’s flexible.
“That funding is critical for us to be able to cover underfunded operations, emergencies or situations of armed conflict that are not in the headlines anymore,” says Carla Haddad Mardini, director of Unicef’s division of private fundraising and partnerships.
The International Council was formed in 2017 not only to boost private-sector donations, but to create a powerful group of individuals who could bring their knowledge, expertise, vision, and networks to the organisation, Haddad Mardini says.
“We don’t see them as donors, we see them as partners,” she says.
That’s because the council’s engagement with Unicef goes behind giving. “They support by opening their networks to us, thinking with us about the global problems that make children more vulnerable,” Haddad Mardini says. “It’s invaluable in terms of the advocacy that they do and the influence that they exert.”
The council, of course, also provides needed funding. Since it was formed, members—who give US$1 million when they join—have donated more than US$552 million.
This past year, the council brought on 15 new members, half from countries in the Southern Hemisphere, including India, Vietnam, Indonesia, and Mexico. The incoming chair is Muhammed Aziz Khan, founder and chairman of the Summit Group, a Bangladesh industrial conglomerate, whose foundation is focused on the education of vulnerable children in the country.
“We want this group to be as diverse as possible,” Haddad Mardini says. “They’re not there for their own visibility, they are there to really meaningfully and purposefully make a difference.”
Bernard Taylor, an arbitrator and mediator at Judicial Arbitration and Mediation ADR Services and a retired partner with Alston & Bird, an Atlanta-based international law firm, has been an active supporter of Unicef for years, joining its Southeast Regional Board in the U.S. in 2007. In 2018, he joined the council and this past summer, became chair of the organisation’s National Board.
One of Taylor’s earliest experiences with Unicef was a trip to Madagascar not long after the island in the southwest Indian Ocean off the coast of Africa had been hit by successive cyclones.
“It was really eye-opening from the standpoint of seeing the despair that so many people were living through and that the children were living through,” Taylor says. After returning home and taking his children on a trip to the local mall to buy supplies for a school project, he was overwhelmed by the abundance that surrounded them.
“Just a short plane ride away, people were living in despair and death—we had to do something about that, and what I saw was that Unicef was doing something about it,” he says. “That’s how I got involved and committed.”
Often, the council responds to emergencies such as the urgent need for global vaccine distribution during the pandemic. In 2022, the council raised US$3.2 million to support Unicef’s work in Afghanistan, and another US$5.5 million in response to the war in Ukraine.
But as Haddad Mardini says, the council also goes beyond check-writing.
“We are all focused on pulling together our resources, our expertise,
our networks,” Taylor says. “As a private philanthropy, we’re able to be nimble, to be fast and flexible in ways that can address the issues that Unicef is struggling with. As a council member, I’m able to utilise my influence with peers and business leaders and even governmental entities.”
Recently, he spoke with one of Georgia’s U.S. senators to inform him about Unicef’s activities and to get his support. “Maybe you would call us extenders of influence—we increase, substantially, the influence and the ability of Unicef to do its work.”
The experience of Taylor, O’Farrell and others as private sector executives can also be influential to the thinking of Unicef’s executives, Jones says.
“They’re bringing their private sector experience and what they’re seeing in their partnerships,” she says. “It’s a space where they feel comfortable being very open and candid. It’s a nice dialogue with leadership.”
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At least for people who carry the APOE4 genetic variant, a juicy steak could keep the brain healthy.
Must even steak be politicised? The American Heart Association recently recommended eating more “plant-based” protein in a move to counter the Health and Human Services Department’s new guidelines calling for more red meat.
Few would argue that eating a Big Mac a day is good for you.
On the other hand, growing evidence, including a study last month in the Journal of the American Medical Association, suggests that eating more meat—particularly unprocessed red meat—can reduce the risk of Alzheimer’s in the quarter or so of people with a particular genetic predisposition.
The APOE4 gene variant is one of the biggest risk factors for Alzheimer’s.
You inherit one copy of the APOE gene from each parent. The most common variant is APOE3; the least is APOE2.
The latter carries a lower risk of Alzheimer’s, while the former is neutral. A quarter of people carry one copy of the APOE4 variant, and about 2% carry two.
APOE4 is more common among people with Northern European and African ancestry. In Europe the variant increases with latitude, and is present in as many as 27% of people in northern countries versus 4% in southern ones. God smiled on the Italians and Greeks.
For unknown reasons, the APOE4 variant increases the risk of Alzheimer’s far more for women than men.
Women’s risk multiplies roughly fourfold if they have one copy and tenfold if they have two. Men with a single copy show little if any higher risk, while those with two face four times the risk.
What makes APOE4 so pernicious? Scientists don’t know exactly, but the variant is also associated with higher cholesterol levels—even among thin people who eat healthily.
Scientists have found that cholesterol builds up in brain cells of APOE4 carriers, which can disrupt communications between neurons and generate amyloid plaque, an Alzheimer’s hallmark.
The Heart Association’s recommendation to eat less red meat may be sound advice for people with high cholesterol caused by indulgent diets.
But a diet high in red meat may be better for the brains of APOE4 carriers.
In the JAMA study, researchers at Sweden’s Karolinska Institute examined how diet, particularly meat consumption, affects dementia risk among seniors with the different APOE variants.
Higher consumption of meat, especially unprocessed red meat, was associated with significantly lower dementia risk for APOE4 carriers.
APOE4 carriers who consumed the most meat—the equivalent of 4.5 ounces a day—were no more likely to develop dementia than noncarriers. (
The study controlled for other variables that are known to affect Alzheimer’s risk including sex, age, physical activity, smoking, alcohol consumption and education.)
APOE4 carriers who ate the most unprocessed meat were at significantly lower risk of dying over the study’s 15-year period and had lower cholesterol than carriers who ate less. Go figure. Noncarriers, however, didn’tenjoy similar benefits from eating more red meat.
The study’s findings are consistent with two large U.K. studies.
One found that each additional 50 grams of red meat (equivalent to half a hamburger patty) that an APOE4 carrier consumed each day was associated with a 36% reduced risk of dementia.
The other found that older women who carried the APOE4 variant and consumed at least one serving a day of unprocessed red meat had a cognitive advantage over carriers who ate less than half a serving, and that this advantage was of roughly equal magnitude to the cognitive disadvantage observed among APOE4 carriers in general.
In all three studies, eating more red meat appeared to negate the increased genetic risk of APOE4.
Perhaps one reason men with the variant are at lower Alzheimer’s risk than women is that men eat more red meat.
These findings might cause chagrin to women who rag their husbands about ordering the rib-eye instead of the heart-healthy salmon.
But remember, the cognitive benefits of eating more red meat appear isolated to APOE4 carriers.
Nutrition is complicated, and categorical recommendations—other than perhaps to avoid nutritionally devoid foods—would best be avoided by governments and health bodies.
Readers can order an at-home test from any number of companies to screen for the APOE4 variant.
The Swedish researchers hypothesize that APOE4 carriers may be evolutionarily adapted to carnivorous diets, since the variant is believed to have emerged between one million and six million years ago during a “hypercarnivorous” period in human history.
The other two APOE variants originated more recently, during eras when humans ate more plants.
APOE4 carriers may absorb more nutrients from meat than plants, the researchers surmise. Vitamin B12—low levels have been associated with cognitive decline—isn’t naturally present in plant-based foods but is abundant in red meat.
Foods high in phytates (such as grains and beans) can interfere with absorption of zinc and iron (also high in red meat), which naturally declines with age. So maybe don’t chuck your steak yet.
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